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Hepatic interferon‐gamma‐induced protein‐10 expression is more strongly associated with liver fibrosis than interleukin‐28 B single nucleotide polymorphisms in hepatocellular carcinoma resected patients with chronic hepatitis C
Author(s) -
Konishi Hideyuki,
Shirabe Ken,
Yoshiya Shohei,
Ikeda Tetsuo,
Ikegami Toru,
Yoshizumi Tomoharu,
IkawaYoshida Ayae,
Motomura Takashi,
Fukuhara Takasuke,
Maehara Yoshihiko
Publication year - 2013
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12070
Subject(s) - hepatocellular carcinoma , isg15 , single nucleotide polymorphism , hepatitis c virus , minor allele frequency , hepatic fibrosis , genotype , medicine , fibrosis , interferon , hepatitis c , interferon stimulated gene , snp , gastroenterology , immunology , biology , gene , virus , receptor , biochemistry , innate immune system , ubiquitin
Aim Single nucleotide polymorphisms ( SNP ) around IL‐28B and interferon ( IFN )‐stimulated gene ( ISG ) expression are predictors of response to standard therapy involving IFN for chronic hepatitis C virus ( HCV ) infection. We analyzed the association between these predictors to improve the prediction of the response to IFN therapy after liver resection for hepatocellular carcinoma ( HCC ). Methods Data were collected from 74 patients with HCV ‐induced HCC . The IL‐28B genotype and hepatic ISG m RNA levels were analyzed to clarify their association, focusing on the progression of liver fibrosis. Results Fifty patients were identified as having major alleles ( rs8099917 TT ) and the remaining 24 patients had minor alleles ( rs8099917 TG or GG ). Hepatic ISG15 expression was lower in the IL‐28B major group than that in the IL‐28B minor group ( P < 0.005). IP ‐10 expression was similar between the IL‐28B major and minor groups ( P = 0.44). IP ‐10 expression was elevated with advancing stages of liver fibrosis in HCV infected patients ( P = 0.005). In patients with mild or no fibrosis, the IL‐28B major group had lower IP ‐10 expression than the IL‐28B minor group ( P = 0.02). However, in patients with advanced fibrosis, IP ‐10 expression was not different between the IL‐28B major and minor groups ( P = 0.66). Conclusion Hepatic ISG15 expression is associated with IL‐28B polymorphisms, while IP ‐10 is strongly affected by liver fibrosis.