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Survey of non‐ B , non‐ C liver cirrhosis in J apan
Author(s) -
Suzuki Yasuaki,
Ohtake Takaaki,
Nishiguchi Shuhei,
Hashimoto Etsuko,
Aoyagi Yutaka,
Onji Morikazu,
Kohgo Yutaka
Publication year - 2013
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12056
Subject(s) - cirrhosis , chemistry , medicine
Aim The aim of this survey was to reveal clinical features for each etiology of non‐ B , non‐ C liver cirrhosis ( NBNC LC ) in J apan. Methods I n a nationwide survey of NBNC LC in J apan at the 15th G eneral M eeting of the J apan S ociety of H epatology, 6999 NBNC LC patients were registered at 48 medical institutions. Epidemiological and clinical factors were investigated. Results The percentage of NBNC LC among LC patients was 26%. NBNC LC patients were categorized into 11 types according to etiological agents: non‐alcoholic steatohepatitis ( NASH ), 14.5%; alcoholic liver disease ( ALD ), 55.1%; fatty liver disease ( FLD ), except NASH , ALD , and other known etiology, 2.5%; primary biliary cirrhosis, 8.0%; other biliary cirrhosis, 0.8%; autoimmune hepatitis, 6.8%; metabolic disease, 0.6%; congestive disease, 0.8%; parasitic disease, 0.2%; other known etiology, 0.2%; and unknown etiology, 10.5%. Compared with previous surveys, the percentage of ALD remained unchanged, whereas that of NASH increased. The mean age and percentage of females were significantly higher in NASH patients than in ALD and FLD patients. Prevalence of diabetes mellitus was significantly higher in NASH and FLD patients than in ALD ones. Prevalence of hepatocellular carcinoma ( HCC ) in NBNC LC patients was 35.9%. Among NASH , ALD and FLD patients, 50.9%, 34.3% and 54.5% had HCC , respectively. Positivity of hepatitis B core antibody was significantly higher in HCC patients than in those without HCC (41.1% vs 24.8%). Conclusion This survey determined the etiology of NBNC LC in J apan. These results should contribute new ideas toward understanding NBNC LC and NBNC HCC .