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Warming effect on miriplatin–lipiodol suspension for potential use as a chemotherapeutic agent for transarterial chemoembolization of hepatocellular carcinoma: In vitro study
Author(s) -
Kora Shinichi,
Urakawa Hiroshi,
Mitsufuji Toshimichi,
Osame Akinobu,
Higashihara Hideyuki,
Ohki Toshihiro,
Yoshimitsu Kengo
Publication year - 2013
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12050
Subject(s) - lipiodol , hepatocellular carcinoma , viscosity , reproducibility , medicine , suspension (topology) , biomedical engineering , chemistry , materials science , chromatography , mathematics , homotopy , pure mathematics , composite material
Aim To elucidate whether warming may reduce the viscosity of miriplatin–lipiodol suspension ( MPT / LPD ) and also the injection pressure through microcatheters, for potential use as a chemotherapeutic agent of transarterial chemoembolization ( TACE ) for hepatocellular carcinoma ( HCC ). Methods Viscosity of MPT / LPD prepared at on‐label dose was measured in vitro at 25°C, 30°C, 40°C, 50°C and 60°C using capillary tube method. Reproducibility of viscosity change was also tested. Injection pressure through two different commercially available microcatheters was measured using a rheometer. Data sampling was performed at least twice for each measurement. Results Viscosity of MPT / LPD was significantly reduced as the temperature was elevated ( R 2 = 0.9586, P < 0.0001, Pearson's correlation); at 40°C, it was almost half of that at room temperature (25°C). Repeated warming and cooling down of MPT / LPD revealed good reproducibility of viscosity change. Injection pressure through either microcatheter showed significant reduction when MPT / LPD was warmed ( P < 0.05, Spearman's rank correlation coefficient). Conclusion The viscosity and injection pressure through microcatheters of MPT / LPD was confirmed to reduce significantly as the temperature is elevated. MPT / LPD warmed to 40°C has half viscosity as that at room temperature and is considered suitable for clinical use. Warming MPT / LPD may have potential to facilitate the procedure of TACE for HCC .