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Antitumor efficacy of transcatheter arterial chemoembolization with warmed miriplatin in hepatocellular carcinoma
Author(s) -
Seko Yuya,
Ikeda Kenji,
Kawamura Yusuke,
Fukushima Taito,
Hara Tasuku,
Sezaki Hitomi,
Hosaka Tetsuya,
Akuta Norio,
Suzuki Fumitaka,
Kobayashi Masahiro,
Suzuki Yoshiyuki,
Saitoh Satoshi,
Arase Yasuji,
Kumada Hiromitsu
Publication year - 2013
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12041
Subject(s) - medicine , transcatheter arterial chemoembolization , hepatocellular carcinoma
Aim Patients with unresectable hepatocellular carcinoma ( HCC ) often undergo transcatheter arterial chemoembolization ( TACE ). Miriplatin is a lipophilic cisplatin derivative used in TACE that is effective in HCC . However, the difference in antitumor efficacy between warmed versus room temperature miriplatin is unclear. Methods Chemotherapy efficacy was evaluated by dynamic computed tomography 1–3 months after TACE , according to the M odified R esponse E valuation C riteria in S olid T umors. A total of 203 patients with HCC who received TACE with miriplatin for the first time were included in a follow‐up study to retrospectively investigate its efficacy and safety. Overall, 45 patients underwent TACE with warmed (40° C ) miriplatin and 158 patients received TACE with room temperature miriplatin. Results Seventy patients (44.3%) treated with room temperature miriplatin and 32 patients (71.1%) who received warmed miriplatin experienced complete or partial responses. Multivariate analysis identified miriplatin temperature (warmed miriplatin, risk ratio ( RR ) = 2.26, P = 0.047), tumor number (solitary, RR = 3.48, P = 0.007), α‐fetoprotein ( AFP ) level (<50 ng/ mL , RR = 2.35, P = 0.012) and history of TACE (no history, RR = 2.22, P = 0.041) as predictors of objective response following TACE with miriplatin, and no serious complications were observed. Conclusion Warm temperature, solitary tumors, low AFP level and first TACE are significant and independent predictors of objective response after TACE using miriplatin. These results suggest that warmed miriplatin can be considered as one of the standard treatments for unresectable HCC .