Premium
Biomarkers for the diagnosis of acute cellular rejection in liver transplant recipients: A review
Author(s) -
Verhelst Xavier P.D.,
Troisi Roberto I.,
Colle Isabelle,
Geerts Anja,
van Vlierberghe Hans
Publication year - 2013
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12012
Subject(s) - biomarker , medicine , gold standard (test) , biomarker discovery , omics , liver biopsy , liver transplantation , diagnostic biomarker , pathology , bioinformatics , biopsy , transplantation , cancer , biology , proteomics , biochemistry , gene
The gold standard for the diagnosis of acute cellular rejection ( ACR ) is a liver biopsy. The quest for an alternative non‐invasive biomarkers has been long and is ongoing. However, an efficient and useful biomarker has not been developed yet. In this manuscript, we review all possible candidate biomarkers that have been studied in recent years, starting with cytokines and ending with an overview of different newly discovered “omics”. Promising paths are being explored but a valid non‐invasive biomarker has not been discovered yet.