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Early extensive viremia, but not rs8099917 genotype, is the only predictor for cholestatic hepatitis C after living‐donor liver transplantation
Author(s) -
Ikegami Toru,
Shirabe Ken,
Fukuhara Takasuke,
Furusyo Norihiro,
Kotoh Kazuhiro,
Kato Masaki,
Shimoda Shinji,
Aishima Shinichi,
Soejima Yuji,
Yoshizumi Tomoharu,
Maehara Yoshihiko
Publication year - 2013
Publication title -
hepatology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.123
H-Index - 75
eISSN - 1872-034X
pISSN - 1386-6346
DOI - 10.1111/hepr.12003
Subject(s) - medicine , viremia , titer , gastroenterology , liver transplantation , hepatitis c , ribavirin , hepatitis c virus , genotype , univariate analysis , interleukin 28b , transplantation , immunology , virology , virus , multivariate analysis , biology , biochemistry , gene
Aim Cholestatic hepatitis C is one of the most serious but still unaddressed disorders after liver transplantation. Methods In this study, we analyzed 49 patients who underwent living‐donor liver transplantation ( LDLT ) to treat hepatitis C virus ( HCV ) infection. Results Five patients developed cholestatic hepatitis C , with total bilirubin of 15.2 ± 3.1 mg/dL at diagnosis 6.2 ± 1.0 weeks after LDLT . Univariate analysis showed that larger graft to standard liver volume ratio, higher HCV RNA titer at 2 weeks, earlier peak HCV RNA titer and cytomegalovirus infection were the significant risk factors. The development of cholestatic hepatitis C was not significantly associated with interleukin‐28 B genotype (rs8099917); four out of five affected patients had the T/T genotype. Multivariate analysis showed that higher HCV RNA titer at 2 weeks was the only significant factor ( P = 0.026) for the development of cholestatic hepatitis C . Receiver–operator curve analysis showed that that HCV RNA titer of more than 7.2 log 10 IU/mL was the optimal cut‐off for characterizing cholestatic hepatitis C . All of the patients were serum HCV RNA negative after treatment with pegylated interferon and ribavirin and all the patients are alive. Conclusion Early extensive viremia, but not the rs8099917 genotype, was the only predictor for cholestatic hepatitis C after LDLT .