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Eradication of Helicobacter pylori infection decreases risk for dyslipidemia: A cohort study
Author(s) -
Park Yewan,
Kim Tae Jun,
Lee Hyuk,
Yoo Heejin,
Sohn Insuk,
Min Yang Won,
Min ByungHoon,
Lee Jun Haeng,
Rhee PoongLyul,
Kim Jae J.
Publication year - 2021
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12783
Subject(s) - dyslipidemia , medicine , helicobacter pylori , cohort study , cohort , incidence (geometry) , prospective cohort study , waist , longitudinal study , helicobacter pylori infection , gastroenterology , body mass index , obesity , pathology , physics , optics
Background Previous studies have suggested a relationship between Helicobacter pylori infection and dyslipidemia; however, large‐scale longitudinal studies have not elucidated this association. This study assessed the longitudinal effects of H. pylori infection and eradication on lipid profiles in a large cohort. Methods This cohort study included 2,626 adults without dyslipidemia at baseline, who participated in a repeated, regular health‐screening examination, which included upper gastrointestinal endoscopy, between January 2009 and December 2018. The primary outcome was incident dyslipidemia at follow‐up. Results During the 10,324 person‐years of follow‐up, participants with persistent H. pylori infection had a higher incidence rate (130.5 per 1,000 person‐years) of dyslipidemia than those whose infections had been successfully controlled (98.1 per 1,000 person‐years). In a multivariable model adjusted for age, sex, waist circumference, smoking status, alcohol intake, and education level, the H. pylori eradication group was associated with a lower risk of dyslipidemia than the persistent group (HR, 0.85; 95% CI, 0.77–0.95; p = 0.004). The association persisted after further adjustment for baseline levels of low‐density and high‐density lipoprotein cholesterol (HR, 0.87; 95% CI, 0.79–0.97; p = 0.014). Conclusions H. pylori infection may play a pathophysiologic role in the development of dyslipidemia, whereas H. pylori eradication might decrease the risk of dyslipidemia.