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A lucid review of Helicobacter pylori ‐induced DNA damage in gastric cancer
Author(s) -
Fu Li,
Xie Chuan
Publication year - 2019
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12631
Subject(s) - helicobacter pylori , dna damage , cancer , carcinogen , dna , oxidative stress , oxidative damage , inflammation , cancer research , medicine , biology , immunology , genetics
Helicobacter pylori ( H pylori ) is the main risk factor for gastric cancer (GC). In recent years, many studies have addressed the effects of H pylori itself and of H pylori ‐induced chronic inflammation on DNA damage. Unrepaired or inappropriately repaired DNA damage is one possible carcinogenic mechanism. We may conclude that H pylori ‐induced DNA damage is one of the carcinogenic mechanisms of GC. In this review, we summarize the interactions between H pylori and DNA damage and the effects of H pylori ‐induced DNA damage on GC. Then, focusing on oxidative stress, we introduce the application of antioxidants in GC. At the end of this review, we discuss the outlook for further research on H pylori ‐induced DNA damage.