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Helicobacter pylori infection and prevalence of stroke
Author(s) -
ShindlerItskovitch Tali,
Chodick Gabriel,
Shalev Varda,
Muhsen Khitam
Publication year - 2019
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12553
Subject(s) - medicine , helicobacter pylori , odds ratio , stroke (engine) , confounding , confidence interval , disease , logistic regression , gastroenterology , urea breath test , peptic ulcer , breath test , helicobacter pylori infection , mechanical engineering , engineering
Background Helicobacter pylori causes peptic ulcer disease; however, conflicting evidence exists regarding its role in extragastric conditions. We aimed to examine associations of H pylori infection and peptic ulcer disease with stroke. Methods A cross‐sectional study was undertaken using data of 147 936 individuals aged 25‐95 years who underwent the urea breath test during 2002‐2012, based on the computerized database of the second largest health maintenance organization in Israel. Logistic regression models were fitted to control for potential confounders. Results Overall, 1397 (0.9%) patients had stroke and 76 965 (52.0%) had a H pylori positive test. The likelihood of prevalent stroke increased in relation to H pylori infection: adjusted odds ratio (aOR) 1.16 (95% confidence intervals [CI]: 1.04‐1.29), gastric ulcer: aOR 1.50 (95% CI: 1.18‐1.91), and duodenal ulcer: aOR 1.25 (95% CI: 1.07‐1.46). Conclusions The results support the premise that stroke may be associated with a history of H pylori infection.