Premium
Levels of malondialdehyde in the gastric juice: Its association with Helicobacter pylori infection and stomach diseases
Author(s) -
Wang YaoKuang,
Chiang WeiChih,
Kuo FuChen,
Wu MengChieh,
Shih HsiangYao,
Wang Sophie S.W.,
Liu ChungJung,
Chen YenHsu,
Wu DengChyang,
Su WeiWen,
Huang YeouLih
Publication year - 2018
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12460
Subject(s) - gastroenterology , malondialdehyde , helicobacter pylori , medicine , intestinal metaplasia , gastritis , chronic gastritis , cancer , stomach , gastric mucosa , oxidative stress
Background Helicobacter pylori ( H. pylori ) infection causes elevation of lipid peroxidation product malondialdehyde (MDA) and this association may be due to the bacterium causing reactive oxygen species‐mediated damage to DNA in the gastric epithelium. The aim of this study was to investigate the gastric juice MDA levels in relation to H. pylori infection and associated gastric diseases. Methods Gastric juice samples were obtained from 117 patients undergoing endoscopy, and gastric juice MDA levels were determined by high‐performance liquid chromatography (HPLC) system. We compared the MDA levels between patients with and without H. pylori infection and assessed the differences of MDA levels between chronic gastritis, gastric intestinal metaplasia, and gastric cancer postsurgical resection. Results Malondialdehyde levels in gastric juice were significantly higher in chronic gastritis patients with H. pylori infection than in those without H. pylori infection ( P < .0001). In patients without H. pylori infection, patients with gastric intestinal metaplasia and gastric cancer postsurgical resection had significantly higher gastric juice MDA level than patients with chronic gastritis. As a whole, patients with gastric intestinal metaplasia and gastric cancer postsurgical resection also had significantly higher MDA levels in gastric juice as compared to patients with chronic gastritis ( P < .01). However, the difference of gastric juice MDA levels between gastric intestinal metaplasia and gastric cancer postsurgical resection was not significant. Conclusion Malondialdehyde in gastric juice could be used as a potential diagnostic biomarker for H. pylori infection and associated gastric diseases. The gastric juice MDA levels increased proportionally with the severity of gastric diseases.