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First evidence of bacterial translocation from the intestinal tract as a route of Helicobacter cinaedi bacteremia
Author(s) -
Araoka Hideki,
Baba Masaru,
Okada Chikako,
Kimura Muneyoshi,
Sato Tomoaki,
Yatomi Yutaka,
Moriya Kyoji,
Yoneyama Akiko
Publication year - 2018
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12458
Subject(s) - bacteremia , pulsed field gel electrophoresis , medicine , chromosomal translocation , microbiology and biotechnology , helicobacter , blood culture , gastroenterology , helicobacter pylori , biology , genotype , antibiotics , gene , biochemistry
Background The route of Helicobacter cinaedi bacteremia has not yet been clarified. Although bacterial translocation from the intestinal tract into the circulation has been suggested, it has not been demonstrated thus far. The objective of this study was to investigate the port of entry of this bacterium. Material and Methods We conducted a retrospective study on patients with H. cinaedi bacteremia between March 2009 and May 2013. Records of patients in whom H. cinaedi was detected in both blood and stool cultures were extracted. H. cinaedi was identified using gyrB‐targeted PCR . Pulse‐field gel electrophoresis was used to investigate the consistency of the genotypes. Results Seventy‐one patients were diagnosed with H. cinaedi bacteremia during the study period. H. cinaedi was detected in both blood and stool samples of 21 patients. Pulse‐field gel electrophoresis was used to investigate the consistency of the genotypes in 18 evaluable strains (from 9 patients). The pulse‐field gel electrophoresis patterns of the stool‐ and blood‐derived strains of H. cinaedi were consistent among all 9 patients. Most of the 9 patients analyzed were immunocompromised and being treated with anticancer drugs or steroids, which suggests reduced intestinal immunity. Conclusions This is the first study to demonstrate that bacterial translocation from the intestinal tract could represent one route of H. cinaedi bacteremia.