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Gastric cancer pathogenesis
Author(s) -
Berger Hilmar,
Marques Miguel S.,
Zietlow Rike,
Meyer Thomas F.,
Machado Jose C.,
Figueiredo Ceu
Publication year - 2016
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12338
Subject(s) - epigenetics , biology , cancer , cancer research , cell cycle , cell growth , gene , carcinogenesis , pathogenesis , suppressor , apoptosis , cell , genetics , immunology
Gastric cancer ( GC ) results from a multistep process that is influenced by Helicobacter pylori infection, genetic susceptibility of the host, as well as of other environmental factors. GC results from the accumulation of numerous genetic and epigenetic alterations in oncogenes and tumor suppressor genes, leading to dysregulation of multiple signaling pathways, which disrupt the cell cycle and the balance between cell proliferation and cell death. For this special issue, we have selected to review last year's advances related to three main topics: the cell of origin that initiates malignant growth in GC , the mechanisms of direct genotoxicity induced by H. pylori infection, and the role of aberrantly expressed long noncoding RNA s in GC transformation. The understanding of the molecular basis of GC development is of utmost importance for the identification of novel targets for GC prevention and treatment.