Premium
Eradication Rates of Helicobacter pylori in Korea Over the Past 10 years and Correlation of the Amount of Antibiotics Use: Nationwide Survey
Author(s) -
Shin Woon Geon,
Lee Sang Woo,
Baik Gwang Ho,
Huh Kyu Chan,
Lee Sang In,
Chung JunWon,
Jung Woon Tae,
Park Moo In,
Jung Hyekyung,
Kim Heung Up,
Kim Jeong Hwan,
Seol Sang Young,
Yoon Soon Man,
Jeon Seong Woo,
Hong Su Jin,
Kim Gwang Ha,
Lee Dong Ho,
Kim Hyun Soo,
Choi Suck Chei,
Kang Hee Mo,
Lee Joongyub,
Kim Jae Gyu,
Kim Jae J.
Publication year - 2016
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12279
Subject(s) - helicobacter pylori , antibiotics , medicine , correlation , microbiology and biotechnology , biology , mathematics , geometry
Background The efficacy of proton‐pump inhibitor–amoxicillin–clarithromycin therapy for H. pylori eradication has decreased over time. Objective We assessed the trend of H. pylori eradication rates over the last 10 years and the relationship between the eradication rates and the amount of macrolide antibiotic use in a country with a high prevalence of H. pylori infection. Methods This vast nationwide multicenter study was conducted with 34,139 adults treated for H. pylori infection from January 2001 to December 2010. The defined daily dose per km 2 ( DSD ) of macrolide antibiotics was calculated (n = 141,019) using the Health Insurance Review & Assessment data base from 2008 to 2010 in the two cities which had the lowest (Jeju city) or highest (Chuncheon city) eradication rate. Results The eradication rates of proton‐pump inhibitor–amoxicillin–clarithromycin therapy ranged 84.9–87.5% from 2001 to 2007, and those of 2008 to 2010 ranged 80.0–81.4% with a decreasing trend ( p < 0.0001). The decreasing trend of eradication rates for the overall first‐line therapy was observed only in three of the seven geographic areas in Korea ( p < 0.0001). The DSD of macrolide antibiotics was significantly higher in Jeju than Cheunchon city (0.85 vs 0.52, p < 0.0001). Conclusions H. pylori eradication rates with clarithromycin‐containing triple therapy in Korea showed a decreasing trend over the past 10 years, although the trend varied among geographic areas. This difference may be associated with the amount of macrolide antibiotic use.