Premium
Emerging Role of Probiotics in the Management of H elicobacter Pylori Infection: Histopathologic Perspectives
Author(s) -
Emara Mohamed H.,
Elhawari Soha A.,
Yousef Salem,
Radwan Mohamed I.,
AbdelAziz Hesham R.
Publication year - 2016
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12237
Subject(s) - helicobacter pylori , medicine , gastroenterology , atrophic gastritis , probiotic , gastritis , discontinuation , antrum , gastric mucosa , stomach , biology , bacteria , genetics
Background There is growing evidence from preclinical and clinical studies that emphasizes the efficacy of probiotics in the management of Helicobacter (H) pylori infection; it increased the eradication rate, improved patient clinical manifestations and lowered treatment associated side effects. Aim In this review we documented the potential ability of probiotics to ameliorate H. pylori induced histological features. Materials and Methods We searched the available literature for full length articles focusing the role of probiotics on H. pylori induced gastritis from histologic perspectives. Results Probiotics lowered H. pylori density at the luminal side of epithelium, improved histological inflammatory and activity scores both in the gastric corpus and antrum. This effect persists for long period of time after discontinuation of probiotic supplementation and this is probably through an immune mechanism. Conclusions The current evidence support the promising role of probiotics in improving H. pylori induced histopathological features both in gastric antrum and corpus and for long periods of time. Because increased density of H. pylori on the gastric mucosa is linked to more severe gastritis and increased incidence of peptic ulcers, we can infer that a reduction of the density might help to decrease the risk of developing pathologies, probably the progression toward atrophic gastritis and gastric adenocarcinoma. These effects together with improving the H. pylori eradication rates and amelioration of treatment related side effects might open the door for probiotics to be added to H. pylori eradication regimens.