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Holotranscobalamin Levels in Children with Helicobacter Pylori Infection
Author(s) -
Afyoncu Oguz,
Gursel Orhan,
Atay Avni,
Kurekci Emin,
Balamtekin Necati,
Hasimi Adnan,
Ozguven Mehmet A.,
Ozcan Okan
Publication year - 2016
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12232
Subject(s) - medicine , vitamin b12 , gastroenterology , helicobacter pylori infection , helicobacter pylori , homocysteine , urea breath test , breath test
Abstract Background The purpose of this study was to evaluate the association between vitamin B 12 levels and Helicobacter Pylori infection and to examine the clinical usefulness of holotranscobalamin (holoTC) measurement in children. Materials and Methods Thirty patients between 6 and 15 years of age, who were diagnosed as H. pylori infected by C 14 urea breath test, and 26 controls were enrolled in the study. Tests for complete blood count, serum vitamin B 12 and folate, plasma total homocysteine, and holoTC levels were performed in each patient in the study and control groups. Results Mean plasma holoTC concentrations were significantly lower in children with H. pylori infection before treatment (median 23.7 pmol/L (12.9–37.1 pmol/L)) versus after treatment (median 38.2 pmol/L (21.2–61.4 pmol/L)) and controls (median 36.1 pmol/L (12.6–58.7 pmol/L)). Conclusions The findings of our study suggest that H. pylori infection has a reversible negative effect on vitamin B 12 status reflected in a decreased level of plasma holoTC that normalizes upon treatment of the infection, while no change is observed in total plasma vitamin B 12 .