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Is There Any Difference in the Eradication Rate of H elicobacter pylori Infection According to the Endoscopic Stage of Peptic Ulcer Disease?
Author(s) -
Seo Seung In,
Kim Sung Jun,
Kim Hyoung Su,
Shin Woon Geon,
Kim Kyung Ho,
Jang Myoung Kuk,
Lee Jin Heon,
Kim Hak Yang
Publication year - 2015
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12221
Subject(s) - medicine , gastroenterology , helicobacter pylori , peptic ulcer , stage (stratigraphy) , odds ratio , proton pump inhibitor , paleontology , biology
Background The eradication rate of H elicobacter pylori ( H . pylori ) infection might be affected by the degree of inflammation of gastric mucosa represented by the endoscopic stage of peptic ulcer disease ( PUD ). The aims of this study were to evaluate the eradication rates of H . pylori infection according to the endoscopic stage of PUD and to document whether early eradication in the active stage could yield a higher eradication rate in patients with peptic ulcer bleeding ( PUB ). Materials and Methods A total of 1,177 patients with PUD (380 gastric ulcer, 710 duodenal ulcer, and 87 combined ulcer) who received proton‐pump inhibitor ( PPI )‐based triple therapy were included, and the eradication rates were compared by ulcer stage. Univariate and multivariate analyses were conducted to identify factors influencing eradication rate. In PUB , the eradication rates between the early eradication group (≤7 days) and the late eradication group (>7 days) were compared. Results The eradication rates according to endoscopic stage were significantly different in gastric ulcer (active vs healing vs scarring; 84.8% vs 82.7% vs 70.6%, p = .014, respectively), but there were no significant differences in duodenal ulcer (active vs healing vs scarring; 87.6% vs 80.9%% vs 80.9% p = .169, respectively). In multivariate analyses, active ulcer as well as age younger than 50 was a significantly independent predictor of successful eradication (Odds ratio; 2.799, 95% CI ; 1.659–4.723, p = .0001). The eradication rate of the early eradication group was significantly higher than the late eradication group in PUB (89.2% vs 71.9%, 95% CI ; 1.265–8.269, p = .011). Conclusions There was a significant difference in the eradication rate according to the endoscopic stage of gastric ulcer. Active ulcer was an independent predictor of successful eradication. Furthermore, early H. pylori eradication should be considered in patients with PUB to yield a higher eradication rate.