Premium
Helicobacter pylori Infection Increase the Risk of Myocardial Infarction: A Meta‐Analysis of 26 Studies Involving more than 20,000 Participants
Author(s) -
Liu Juan,
Wang Feng,
Shi Songli
Publication year - 2015
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12188
Subject(s) - myocardial infarction , helicobacter pylori , medicine , meta analysis , helicobacter pylori infection , infarction , disease , risk factor , cardiology , gastroenterology
Background Myocardial infarction is a fatal cardiovascular disease and one of the most common death causes all around the world. The aim of the meta‐analysis was to quantify the risk of myocardial infarction associated with Helicobacter pylori infection. Methods A literature search was performed to identify studies published before 14 July, 2014, for relevant risk estimates. Fixed and random effect meta‐analytical techniques were conducted for myocardial infarction. Results Twenty‐six case–control studies involving 5829 myocardial infarction patients and more than 16,000 controls were included. Helicobacter pylori infection was associated with an increased risk of myocardial infarction ( OR : 2.10, 95% CI : 1.75–2.53, p = .06). We also discovered a significant association between the bacteria and risk of myocardial infarction in young people ( OR : 1.93, 95% CI : 1.41–2.66, p = .07), in elder people ( OR : 2.02, 95% CI : 1.60–2.54, p = .29), in Caucasians ( OR : 2.29, 95% CI : 1.99–2.63, p = .12), and in Asians ( OR : 1.75, 95% CI : 1.12–2.73, p = .08). Conclusion Our meta‐analyses suggested a possible indication of relationship between Helicobacter pylori infection and the risk of myocardial infarction. The pathogenicity might not be affected by age and race. More researches should be conducted to explore the mechanisms involved.