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Serum Antibody Against H elicobacter pylori FlaA and Risk of Gastric Cancer
Author(s) -
Tian Wenjing,
Jia Yunhe,
Yuan Kexin,
Huang Lina,
Nadolny Christina,
Dong Xiaoqun,
Ren Xiyun,
Liu Jingjing
Publication year - 2014
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12095
Subject(s) - antibody , serostatus , helicobacter pylori , gastroenterology , receiver operating characteristic , medicine , cancer , biomarker , risk factor , area under the curve , immunology , biology , biochemistry , human immunodeficiency virus (hiv) , viral load
Abstract Background Helicobacter pylori (H. pylori) infection is a major risk factor for gastric cancer ( GC ); however, only a minority of infected individuals develops GC . We aim to assess the association between serostatus of antibody against H. pylori flagellin A (FlaA) and risk of GC and to evaluate the value of serum FlaA antibody as a novel screening biomarker for GC risk. Methods A hospital‐based case–control study including 232 cases and 264 controls was conducted. Logistic regression was adopted to analyze the association between the serostatus of FlaA antibody and risk of GC . Serum FlaA antibody was measured by an enzyme‐linked immunosorbent assay ( ELISA ). Receiver operating characteristic ( ROC ) curve was used to evaluate the screening efficacy and to identify a cutoff point of serum FlaA antibody level. Results Helicobacter pylori infection was associated with an increased risk of GC ( p = .007). A positive association between serum FlaA antibody and GC risk was observed in overall subjects and H. pylori‐ positive subjects ( OR [95% CI ]: 6.8 [4.3–10.7] and 6.9 [3.6–13.4], respectively; p < .001). The seropositivity of FlaA antibody was strongly related to GC risk in a dose‐dependent manner ( p for trend < .001). The optimal cutoff value ( OD ) was 0.1403, providing a sensitivity of 74.1% and a specificity of 64.4%. The area under the ROC curve ( AUC ) was 0.74 in overall subjects and 0.73 in H. pylori ‐positive subjects, respectively. Conclusions FlaA was an independent risk factor for H. pylori ‐related GC . Serum FlaA antibody may serve as a novel noninvasive biomarker for early detection of GC .