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Pathogenesis of H elicobacter pylori Infection
Author(s) -
Cid Trinidad Parra,
Fernández Miryam Calvino,
Benito Martínez Selma,
Jones Nicola L.
Publication year - 2013
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12076
Subject(s) - virulence , pathogenesis , caga , pathogenicity island , helicobacter pylori , disease , biology , host factors , virulence factor , host (biology) , pathogenicity , immunology , microbiology and biotechnology , autophagy , epigenetics , medicine , genetics , gene , virus , apoptosis , pathology
Abstract H elicobacter pylori infection and disease outcome are mediated by a complex interplay between bacterial, host, and environmental factors. Over the past year, our understanding of this complex interplay has been improved by a variety of studies focusing on both host and bacterial factors. These include studies assessing novel virulence factors as well as those most frequently associated with severity of disease outcome including cag A and the cag pathogenicity island, and the vacuolating cytotoxin. Several studies have focused on regulation of virulence factors by environmental factors. In addition, mechanisms by which bacterial virulence factors influence the host response and disease, by inducing epigenetic changes, autophagy and altered oxidative stress have also been elucidated. This review highlights key findings in the pathogenesis of H . pylori infection reported over the past year.