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Helicobacter pylori and Nonmalignant Diseases
Author(s) -
den Hollander Wouter J.,
Sostres Carlos,
Kuipers Ernst J.,
Lanas Angel
Publication year - 2013
Publication title -
helicobacter
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.206
H-Index - 79
eISSN - 1523-5378
pISSN - 1083-4389
DOI - 10.1111/hel.12074
Subject(s) - helicobacter pylori , medicine , gastroenterology
Declining H elicobacter pylori prevalence rates have resulted in a decrease of peptic ulcer bleeding incidence. Moreover, eradication reduces peptic ulcer recurrence rate. Newer studies confirm that H . pylori eradication lowers the risk of recurrent peptic ulcer bleeding. Guidelines therefore advocate a test‐and‐treat strategy for patients with a history of ulcer bleeding and NSAID s and/or aspirin use. There is mounting evidence that H . pylori status has no effect on symptoms and treatment efficacy in patients with gastroesophageal reflux disease ( GERD ). Some studies observed an improvement of GERD complaints after H . pylori eradication, which underlines that H . pylori treatment is not contra‐indicated in GERD patients. The exact role of H . pylori in functional dyspepsia ( FD ) remains controversial. However, there is growing consensus that H . pylori ‐positive FD should be assessed as a separate entity. In these patients, eradication can be beneficial and appropriate. Finally, several studies suggest that H . pylori infection may also be associated with beneficial effects for the host. Epidemiologic studies showed an inverse relation between H . pylori infection and asthma and allergy, although data are conflicting and need to be expanded.