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Familial Hemiplegic Migraine and Recurrent Episodes of Psychosis: A Case Report
Author(s) -
LaBianca Sonja,
Jensen Rigmor,
Maagdenberg Arn M.J.M.,
Baandrup Lone,
Bendtsen Lars
Publication year - 2015
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/head.12595
Subject(s) - familial hemiplegic migraine , migraine , aura , psychosis , migraine with aura , medicine , pediatrics , psychiatry , psychology , anesthesia
F amilial hemiplegic migraine ( FHM ) is a rare autosomal dominant form of migraine with motor aura. We present a case report of a father and son with very similar attacks of hemiplegic migraine and recurrent episodes of accompanying psychoses. Previously, such episodes led to hospitalization and extended clinical examinations, which further worsened the psychoses. Since the episodes were recognized as related to the hemiplegic migraine, a treatment strategy combining sleep and sedation was initiated and progression onto psychosis was almost completely avoided in both father and son. Genetic analyses found no causal gene mutation in the three known FHM genes, suggesting that the phenotype is caused by a yet unidentified mutation.