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Photophobia in Primary Headaches
Author(s) -
Rossi Heather L.,
Recober Ana
Publication year - 2015
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/head.12532
Subject(s) - photophobia , neuroscience , medicine , migraine , headaches , psychology , psychiatry
Background Photophobia is a debilitating feature of many headache disorders. Overview Clinical and preclinical research has identified several potential pathways involved in enhanced light sensitivity. Some of these structures include trigeminal afferents in the eye, second‐order neurons in the trigeminal nucleus caudalis, third‐order neurons in the posterior thalamus, modulatory neurons in the hypothalamus, and fourth‐order neurons in the visual and somatosensory cortices. It is unclear to what degree each site plays a role in establishing the different temporal patterns of photophobia across different disorders. Peptides such as calcitonin gene‐related peptide and pituitary adenylate cyclase‐activating polypeptide may play a role in photophobia at multiple levels of the visual and trigeminal pathways. Conclusion While our understanding of photophobia has greatly improved in the last decade, there are still unanswered questions. These answers will help us develop new therapies to provide relief to patients with primary headache disorders.