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Diamine Oxidase rs 10156191 and rs 2052129 Variants Are Associated With the Risk for Migraine
Author(s) -
GarcíaMartín Elena,
Martínez Carmen,
Serrador Mercedes,
AlonsoNavarro Hortensia,
Ayuso Pedro,
Navacerrada Francisco,
Agúndez José A. G.,
JiménezJiménez Félix Javier
Publication year - 2015
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/head.12493
Subject(s) - migraine , diamine oxidase , odds ratio , aura , single nucleotide polymorphism , allele , genotype , migraine with aura , medicine , snp , genetics , histamine , biology , gene , biochemistry , enzyme
Background Histamine has been implicated in the pathogenesis of migraine. We investigated the possible association between functional single nucleotide polymorphisms ( SNP s) in the diamine oxidase gene ( DAO ; chromosome 7q36.1, involved in histamine metabolism) and the risk for migraine. Methods We studied the frequency of the rs 2052129, rs 10156191, rs 1049742, and rs 1049793 genotypes and allelic variants in 197 patients with migraine and 245 healthy controls using a TaqMan ‐based qPCR A ssay. Results The DAO SNP rs 10156191, which is related to decreased DAO enzyme activity, is associated with the risk of developing migraine, particularly in women. The odds ratio ( OR ) for the defect allele positivity is 1.61 (95% confidence interval 1.31‐2.37) for overall migraine patients and 2.08 (1.29‐3.36) for women suffering from migraine. The association was not influenced by confounders such as the age at onset, the presence of aura, positivity of alcohol as a triggering factor, positive family history of aura, or family history of allergy. Multiple regression analyses did not confirm association with the rest of genetic factors. Conclusion Our findings, which should be framed as hypothesis generating, suggest that DAO genotypes and allelic variants are associated with the risk for migraine in C aucasian S panish people, especially in women.