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PRDM 16 rs2651899 Variant Is a Risk Factor for C hinese Common Migraine Patients
Author(s) -
An XingKai,
Ma QiLin,
Lin Qing,
Zhang XiaoRong,
Lu CongXia,
Qu HongLi
Publication year - 2013
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/head.12212
Subject(s) - migraine with aura , migraine , aura , allele , genotype , genome wide association study , case control study , medicine , population , genetics , single nucleotide polymorphism , gastroenterology , biology , gene , environmental health
Objective Recent genome‐wide association studies ( GWAS ) have identified 3 loci in or near PRDM 16 (1p36.32, rs2651899), LRP 1 (12q13.3, rs11172113) and TRPM 8 (2q37.1, rs10166942) in the population‐based Women's Genome Health Study ( WGHS ) of migraine, and 2 loci in or near TRPM 8 and LRP 1 were repeated in E uropean GWAS study. To evaluate whether the same variants are related to migraine in C hinese population, we investigated migraine with aura ( MA ) and migraine without aura ( MO ) patients of C hinese H an ethnicity in mainland C hina.Methods A case‐control study in a cohort of 207 migraine cases and 205 ethnically matched controls was conducted by using the dual‐color fluorescence resonance energy transfer ( FRET ) probes analysis.Results The genotypes of all polymorphisms in 2 groups followed the H ardy– W einberg equilibrium. We found significant differences in allele distribution of rs2651899 variant in PRDM 16 between MO patients and control subjects ( P = .049, OR = 1.335, 95% CI 1.001‐1.782), and there were no difference between MA patients and controls in the frequency of genotype and allele. Also, no significant differences in genotypic and allelic distributions between MA or MO patients and controls were observed in the polymorphisms of rs10166942 of TRPM 8 and rs11172113 of LRP 1, and there was no significant difference comparing male with female in all loci.Conclusion Our data suggested that rs2651899 variant in PRDM 16 plays a potential role in C hinese MO migraine susceptibility, and gender may not play a role.