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Sumatriptan Iontophoretic Transdermal System: History, Study Results, and Use in Clinical Practice
Author(s) -
Pierce Mark,
O'Neill Carol,
Felker Ezra,
Sebree Terri
Publication year - 2013
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/head.12182
Subject(s) - sumatriptan , transdermal , migraine , medicine , nausea , vomiting , anesthesia , iontophoresis , adverse effect , dihydroergotamine , pharmacology , agonist , receptor , radiology
Nausea is a common symptom of migraine, and current treatment guidelines recommend non‐oral formulations for nauseated or vomiting patients. Transdermal delivery of sumatriptan, a 5‐hydroxytryptamine 1B1D agonist with established efficacy in patients with migraine, represents a novel approach to acute treatment. The sumatriptan iontophoretic transdermal system circumvents the gastrointestinal tract by using low‐level electrical energy to transport sumatriptan across the skin. In multiple well‐controlled studies, the sumatriptan transdermal system has shown that it provides consistent drug delivery with low interpatient variability, rapid relief of migraine pain and associated symptoms, and an excellent overall safety profile, with a low incidence of triptan‐sensation adverse events. Patients and health care professionals who have used the sumatriptan transdermal system give it high ratings for ease of use/application. The sumatriptan transdermal system will allow a wide range of patients, especially those who experience migraine‐related nausea or vomiting, to receive the benefits of migraine‐specific therapy.