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Hemodialysis Systems for Intermittent, Semi‐Continuous, and Continuous Therapies in Acute Renal Failure
Author(s) -
Clark William R.,
Soltys Paul J.
Publication year - 1998
Publication title -
home hemodialysis international
Language(s) - English
Resource type - Journals
eISSN - 1542-4758
pISSN - 1480-0225
DOI - 10.1111/hdi.1998.2.1.30
Subject(s) - renal replacement therapy , hemodialysis , medicine , intensive care medicine , end stage renal disease , continuous flow , uremic toxins , broad spectrum , acute kidney injury , dialysis , cardiology , chemistry , combinatorial chemistry , physics , mechanics
As is the case in end‐stage renal disease (ESRD), both intermittent and continuous renal replacement therapies (RRTs) are employed in acute renal failure (ARF). In fact, a continuum of treatment options is available in ARF. At one end of the ARF RRT spectrum is conventional intermittent hemodialysis (IHD), in which relatively high blood and dialysate flow rates are used (typically ≥ 250 and 500 mL/min, respectively). Continuous renal replacement therapies (CRRTs), which employ much lower flow rates, comprise the other end of the spectrum. Finally, hybrid therapies, which combine characteristics of both IHD and CRRT, have recently been described. These therapies’ removal mechanisms for solutes over a broad molecular weight range are discussed. An understanding of these mechanisms is important when determining the amount of therapy that can be provided by any RRTs. Additional studies are required to improve the understanding of solute removal by the various RRT used in ARF.