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Chitotriosidase as a novel biomarker of early atherosclerosis in hemodialysis patients
Author(s) -
Güçlü Aydın,
Yilmaz Mahmut Ilker,
Tokmak Turgut Tursem,
Unal Hilmi Umut,
Karaman Murat,
Gezer Mustafa,
Taş Ahmet,
Aydin İbrahim,
Akçılar Raziye,
Dursun Yusuf
Publication year - 2017
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12451
Subject(s) - hemodialysis , medicine , biomarker , creatinine , gastroenterology , uremia , pathogenesis , intima media thickness , inflammation , cardiology , pathology , carotid arteries , biochemistry , chemistry
Increasing evidence suggests that inflammation and increased macrophage activity have a central role in pathogenesis of atherosclerosis. It is shown that chitotriosidase (CHIT‐1) is a marker of macrophage activity in atherosclerotic plaque, and is found associated with severity of atherosclerotic lesion. There is no data about CHIT‐1 activity of hemodialysis patients in the literature. Thus, we hypothesized that in hemodialysis patients, CHIT‐1 levels might be a novel biomarker in early atherosclerosis. Methods: Forty‐five hemodialysis patients were included in the study (age: 61.93 ± 13.34). Intima media thickness (IMT) was evaluated with high‐resolution B‐mode ultrasonography. Biomarker levels were measured in serum of patients. Findings: We found positive correlation among IMT, age ( R : 0.426, P : 0.004) and, CHIT‐1 value ( R : 0.462, P : 0.001) in spearman correlation analysis. When age, CRP, creatinine, P , Alb, CHIT‐1 were chosen as measures that can effect IMT in multiple regression model, IMT level was related with CHIT‐1 (Beta: 0,396, P : 0.012) and age (Beta: 0,313 P : 0,048) independently. Discussion: In conclusion, this is the first report showing that serum CHIT‐1 level was related independently with carotid IMT in hemodialysis patients. This biomarker might have an unknown role in the development of atherosclerosis during uremia.