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Relationship between non‐alcoholic fatty liver disease and MIA syndrome
Author(s) -
Mikolasevic Ivana,
Stimac Davor,
Racki Sanjin,
Zaputovic Luka,
Devcic Bosiljka,
Jelic Ita,
Lukenda Vesna,
Radic Mladen,
Orlic Lidija
Publication year - 2015
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12280
Subject(s) - medicine , gastroenterology , fatty liver , kidney disease , hemodialysis , malnutrition , serum albumin , disease , population , mortality rate , albumin , metabolic syndrome , steatosis , epidemiology , obesity , environmental health
Non‐alcoholic fatty liver disease ( NAFLD ) is an important factor in the pathogenesis of cardiovascular diseases in the general population. Recently, it has been shown that NAFLD is highly prevalent in chronic kidney disease ( CKD ) patients. Ninety‐four hemodialysis ( HD ) patients were followed for a time period of 18 months or until death. Patient's survival rate was determined in relation to their nutritional and inflammatory state, and the presence of NAFLD . We also investigated the association between the presence of NAFLD and the patients' nutritional and inflammatory state. We did not find any significant association between the clinical parameters of nutritional status and the mortality rate. However, the mortality rate was statistically significantly higher in patients with low serum albumin and high high‐sensitive C‐reactive protein (hs‐ CRP ) levels and in those who had NAFLD . Surprisingly, patients who had received enteral nutrition did not have a better survival rate. The severity of liver steatosis was negatively correlated with the serum albumin levels, while it was positively correlated with hs‐ CRP values. Furthermore, serum albumin levels showed a negative correlation with hs‐ CRP levels. We did not find any significant association between the presence of NAFLD and clinical parameters of nutrition. We have shown that NAFLD could be one more possible example of reverse epidemiology in patients undergoing HD . NAFLD may be the missing link that causally ties malnutrition, inflammation, and atherosclerosis syndrome to the morbidity and mortality in patients undergoing HD .