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Echocardiographic epicardial adipose tissue measurements provide information about cardiovascular risk in hemodialysis patients
Author(s) -
Ulusal Okyay Gülay,
Okyay Kaan,
Polattaş Solak Evşen,
Sahinarslan Asife,
Paşaoğlu Özge,
Ayerden Ebinç Fatma,
Paşaoğlu Hatice,
Boztepe Derici Ülver,
Sindel Şükrü,
Arınsoy Turgay
Publication year - 2015
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12276
Subject(s) - medicine , waist , body mass index , triglyceride , hemodialysis , adipose tissue , endocrinology , lean body mass , cardiology , population , cholesterol , body weight , environmental health
Epicardial adipose tissue ( EAT ) is a cardiovascular risk predictor in general population. However, its value has not been well validated in maintainance hemodialysis ( MHD ) patients. We aimed to assess associations of EAT with cardiovascular risk predictors in nondiabetic MHD patients. In this cross‐sectional study, we measured EAT thickness by transthoracic echocardiography in 50 MHD patients (45.8 ± 14.6 years of age, 37 male). Antropometric measurements, bioimpedance analysis, left ventricular ( LV ) mass, carotis intima media thickness, blood tests, homeostasis model assessment for insulin resistance ( HOMA ‐ IR ) and hemodialysis dose by single‐pool urea clearence index ( spKt/V ) were determined. The mean EAT thickness was 3.28 ± 1.04 mm. There were significant associations of EAT with body mass index (β = 0.590, P < 0.001), waist circumference (β = 0.572, P < 0.001), body fat mass (β = 0.562, P < 0.001), percentage of body fat mass (β = 0.408, P = 0.003), percentage of lean tissue mass (β = −0.421, P = 0.002), LV mass (β = 0.426, P = 0.002), carotis intima media thickness (β = 0.289, P = 0.042), triglyceride/high‐density lipoprotein cholesterol ratio (β = 0.529, P < 0.001), 1/ HOMA ‐ IR (β = −0.386, P = 0.006), and spKt/V (β = −0.311, P = 0.028). No association was exhibited with visfatin C , high‐sensitivity C ‐reactive protein, interleukin‐6, and tumor necrosis factor‐alpha (for all, P > 0.05). Body mass index, waist circumference, body fat mass, percentage of lean tissue mass, LV mass, triglyceride/high‐density lipoprotein cholesterol ratio, HOMA ‐ IR , and spKt/V appeared as independent predictors of EAT . EAT was significantly associated with body fat measures, cardiovascular risk predictors, and dialysis dose in MHD patients.