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Acute renal failure in a patient with mantle cell lymphoma
Author(s) -
Peddi Sandeep,
Ram Rapur,
Kataru Sudheer Reddy,
Chennu Krishna Kishore,
Nandyala Rukumangadha,
Kottu Radhika,
Kumar V. Siva
Publication year - 2015
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12229
Subject(s) - mantle cell lymphoma , medicine , infiltration (hvac) , pathology , lymphoma , blastoid , cyclin d1 , lymph node , immunohistochemistry , kidney , lymph node biopsy , biopsy , renal biopsy , antigen , immunology , cell cycle , physics , cancer , thermodynamics
Mantle cell lymphoma is a rare form of B ‐cell lymphoma. We present a 54‐year‐old gentleman with mantle cell lymphoma. It was diagnosed based on the demonstration of B ‐cell antigens CD 20 and CD 5. It was further confirmed by demonstration of overexpression of cyclin D 1 on these atypical lymphocytes in the immunohistochemical staining. He also had acute renal failure and proteinuria. Renal biopsy revealed crescents and lymphomatous infiltration of tubulointerstitium. The presence of infiltrating cells with similar markers in both the lymph node and the kidney confirmed the infiltration of kidney with lymphomatous cells. Our present patient, after a thorough literature search, is found to be the second one with a glomerular lesion and tubulointerstitial infiltration by malignant lymphoma cells.