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Reprocessing high‐flux polysulfone dialyzers does not negatively impact solute removal in short‐daily online hemodiafiltration
Author(s) -
Melo Natalia C. V.,
Moyses Rosa M. A.,
Elias Rosilene M.,
Castro Manuel C. M.
Publication year - 2014
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12126
Subject(s) - medicine , dialysis , hemodialysis , dialysis adequacy , beta 2 microglobulin , chromatography , urology , surgery , chemistry
There are no studies evaluating the impact of dialyzer reprocessing on solute removal in short‐daily online hemodiafiltration ( OL‐HDF ). Our aim was to evaluate the impact of dialyzer reuse on solute removal in daily OL‐HDF and compare with that in high‐flux short‐daily hemodialysis ( SDH ). Fourteen patients undergoing a SDH program were included. Pre‐dialysis and post‐dialysis blood samples and effluent dialysate were collected in the 1st, 7th, and 13th dialyzer uses in SDH sessions and in daily OL‐HDF sessions. Directly quantified small solute (urea, phosphorus, creatinine, and uric acid) total mass removal ( TM DQ ) and clearance ( K DQ ) were similar when the 1st, 7th, and 13th dialyzer SDH uses were compared with the 1st, 7th, and 13th daily OL‐HDF uses. TM DQ and K DQ of small solutes were similar among analyzed dialyzer uses in SDH sessions and in daily OL‐HDF sessions. β 2 ‐Microglobulin TM DQ and K DQ were statistically higher in daily OL‐HDF dialyzer uses than in the respective SDH uses. There was no difference in β 2 ‐microglobulin TM DQ and K DQ among dialyzer uses in daily OL‐HDF sessions or in SDH sessions. In daily OL‐HDF , albumin loss was significantly different among dialyzer uses (P < 0.001), being lower in the 7th and 13th dialyzer uses than in the first use. Dialyzer reprocessing did not impair solute extraction in daily OL‐HDF . β 2 ‐Microglobulin removal was greater in daily OL‐HDF than in SDH sessions, without significant differences in other solutes extraction. There was a significant reduction in intradialytic albumin loss with dialyzer reprocessing in daily OL‐HDF sessions.