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Does hemodiafiltration reduce vascular stiffness measured by aortic pulse wave velocity compared with high‐flux hemodialysis?
Author(s) -
Charitaki Evangelia,
Davenport Andrew
Publication year - 2014
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12119
Subject(s) - medicine , pulse wave velocity , cardiology , pulse pressure , blood pressure , hemodialysis , arterial stiffness , peripheral , perfusion , photoplethysmogram , aorta , diastole , pulse (music) , brachial artery , filter (signal processing) , detector , computer science , electrical engineering , computer vision , engineering
Hemodialfiltration ( HDF ) has been reported to reduce the frequency of intradialytic hypotension compared with hemodialysis ( HD ). We wished to determine whether HDF resulted in improvement of arterial stiffness compared with HD . We reviewed peripheral blood pressure and pulse wave velocity measurements in a cross‐sectional analysis of stable HDF and HD outpatients. One hundred forty‐one HDF patients were matched to 148 HD patients in terms of age, sex, prevalence of diabetes, peripheral blood pressure, and body mass. Pulse wave velocity was not different between the HD and HDF cohorts (median 9.1 [8.0–10.7] m/s vs. 9.7 [8.5–11.6] m/s). Similarly, there were no differences in central aortic pressure (149.2 ± 30.9 mmHg vs. 151.9 ± 35.2 mmHg), or aortic (39 [25.1–51.2]% vs. 38.6 [25.8–51.4]%) and brachial (3.8 [−24.3 to 26.9]% vs. 3 [−22.4 to 27.1]%) augmentation indices, respectively. Pulse wave velocity did not differ between adult patients treated by HD and HDF , and similarly, there were no differences in central aortic pressure, aortic or brachial augmentation indices, and cardiac diastolic perfusion. Our study suggests that HDF does not appear to offer any benefit over HD in terms of vascular stiffness.