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Lactic acidosis induced by metformin in a chronic hemodialysis patient with diabetes mellitus type 2
Author(s) -
Altun Eda,
Kaya Bülent,
Paydaş Saime,
Sarıakçalı Barış,
Karayaylalı İbrahim
Publication year - 2014
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12109
Subject(s) - medicine , metformin , lactic acidosis , biguanide , diabetes mellitus , vomiting , type 2 diabetes mellitus , hemodialysis , nausea , nephrology , type 2 diabetes , abdominal pain , gastroenterology , anorexia , endocrinology
Metformin is a biguanide group oral antidiabetic drug used for the treatment of type 2 diabetes mellitus. Nausea, vomiting, diarrhea, abdominal pain, and anorexia are the most common adverse effects encountered during treatment. Lactic acidosis is a serious side effect seen with metformin use, and while the incidence of lactic acidosis is similar to other oral antidiabetics, metformin is not recommended to patients with certain risk factors, such as cardiovascular, pulmonary, and renal and liver failure. We describe a chronic hemodialysis patient treated with metformin, presenting to the nephrology department with altered mental status.