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Relationship between G eriatric N utritional R isk I ndex and total lymphocyte count and mortality of hemodialysis patients
Author(s) -
Jung Yeon Soon,
You Gain,
Shin Ho Sik,
Rim Hark
Publication year - 2014
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12077
Subject(s) - medicine , hemodialysis , hazard ratio , confidence interval , gastroenterology , hematocrit , proportional hazards model , lymphocyte , diabetes mellitus , mortality rate , surgery , endocrinology
We examined the relationships between G eriatric N utritional R isk I ndex ( GNRI ), total lymphocyte count ( TLC ), and mortality in hemodialysis ( HD ) patients. We examined GNRI and TLC in 120 maintenance HD patients and followed these patients for 120 months. Predictors of all‐cause death were examined using life table analysis and the C ox proportional hazards model. TLC marginally correlated with GNRI (r = 0.176; p = 0.090) and significantly with phosphorus levels (r = 0.206; p = 0.026). Life table analysis revealed that subjects with a GNRI < 90 (n = 19) had lower survival rates than did those with a GNRI ≥ 90 (n = 101; W ilcoxon's test, p = 0.048), but subjects with a TLC < 1500/mm 3 (n = 76) had similar survival rates compared with subjects with a TLC ≥ 1500/mm 3 (n = 44; Wilcoxon's test, p = 0.500). M ultivariate C ox proportional hazards analyses demonstrated that GNRI is a significant predictor of mortality (hazard ratio 9.315, 95% confidence interval 1.161–74.753, p = 0.036), after adjusting for age, sex, presence of type 2 diabetes mellitus, Kt/ V , normalized protein catabolic rate, hematocrit, phosphorus, systolic blood pressure and TLC . Our findings suggest the TLC may be used as a simple nutritional tool, but may not be a predictor of mortality in HD patients. These findings require confirmation by further studies.