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Pharmacokinetics of meprobamate in overdose treated with continuous venovenous hemodiafiltration ( CVVHDF )
Author(s) -
Ceschi Alessandro,
Berger David,
Dickenmann Michael,
Bodmer Michael
Publication year - 2013
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12047
Subject(s) - medicine , anesthesia , pharmacokinetics , meprobamate , extracorporeal , hemodialysis , respiratory system , respiratory failure , surgery , pharmacology
Abstract We report a case of massive suicidal overdose of meprobamate leading to cardiovascular collapse, respiratory failure, and severe central nervous system depression. We observed first‐order elimination kinetics despite significant overdose, and demonstrated effectiveness of continuous venovenous hemodiafiltration ( CVVHDF ) for extracorporeal removal of meprobamate in this patient. Total body clearance was calculated to be 87 mL/minute, with 64 mL/minute (74%) due to CVVHDF . CVVHDF was stopped after 36 hours, and the patient made an uneventful recovery.