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Platelet‐to‐lymphocyte ratio better predicts inflammation than neutrophil‐to‐lymphocyte ratio in end‐stage renal disease patients
Author(s) -
Turkmen Kultigin,
Erdur Fatih Mehmet,
Ozcicek Fatih,
Ozcicek Adalet,
Akbas Emin Murat,
Ozbicer Aysu,
Demirtas Levent,
Turk Suleyman,
Tonbul H. Zeki
Publication year - 2013
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12040
Subject(s) - medicine , neutrophil to lymphocyte ratio , end stage renal disease , hemodialysis , gastroenterology , inflammation , lymphocyte , tumor necrosis factor alpha , dialysis , c reactive protein , peritoneal dialysis , population , kidney disease , systemic inflammation , immunology , environmental health
Abstract Neutrophil‐to‐lymphocyte ratio ( NLR ) was introduced as a potential marker to determine inflammation in end‐stage renal disease ( ESRD ) patients. Recently, platelet‐to‐lymphocyte ratio ( PLR ) and NLR were found to positively correlated with inflammatory markers including tumor necrosis factor‐α ( TNF ‐α) and interleukin ( IL )‐6 in cardiac and noncardiac patients. Data regarding PLR and its association with inflammation are lacking in hemodialysis ( HD ) and peritoneal dialysis ( PD ) patients. Hence, we aimed to determine the relationship between PLR , NLR , and inflammation in ESRD patients. This was a cross‐sectional study involving 62 ESRD patients (29 females, 33 males; mean age, 49.6 ± 14.6 years) receiving PD or HD for ≥6 months in the D ialysis U nit of N ecmettin E rbakan U niversity. PLR , NLR , C ‐reactive protein, TNF ‐α, IL ‐6 levels were measured. PLR , NLR , serum high sensitive C ‐reactive protein, IL ‐6, and TNF ‐α levels were significantly higher in PD patients when compared with HD patients. ESRD patients with PLR ≥ 140 had significantly higher NLR , IL ‐6, and TNF ‐α levels when compared to patients with PLR < 139. In the bivariate correlation analysis, PLR was positively correlated with NLR , IL ‐6, and TNF ‐α in this population. When we compared the association of PLR and NLR with IL ‐6 (r = 0.371, P = 0.003 vs. r = 0.263, P = 0.04, respectively) and TNF ‐α (r = 0.334, P = 0.008 vs. r = 0.273, P = 0.032, respectively), PLR was found to be superior to NLR in terms of inflammation in ESRD patients. Simple calculation of PLR can predict inflammation better than NLR in ESRD patients.