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Coenzyme Q 10 supplementation and diastolic heart functions in hemodialysis patients: A randomized double‐blind placebo‐controlled trial
Author(s) -
Turk Suleyman,
Baki Aysegul,
Solak Yalcin,
Kayrak Mehmet,
Atalay Huseyin,
Gaipov Abduzhappar,
Aribas Alpay,
Akilli Hakan,
Biyik Zeynep,
Okudan Nilsel,
Gokbel Hakki
Publication year - 2013
Publication title -
hemodialysis international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.658
H-Index - 47
eISSN - 1542-4758
pISSN - 1492-7535
DOI - 10.1111/hdi.12022
Subject(s) - medicine , ventricle , placebo , diastole , isovolumetric contraction , cardiology , hemodialysis , crossover study , blood pressure , alternative medicine , pathology
Coenzyme Q 10 ( C o Q 10) supplementation has been shown to improve diastolic heart function in various patient cohorts. Systolic and diastolic dysfunctions are common in patients with end‐stage renal disease. Favorable effects of C o Q 10 on cardiac functions are yet to be seen in hemodialysis patients. We aimed to evaluate effect of C o Q 10 supplementation on diastolic function in a cohort of maintenance hemodialysis patients. This was a prospective, double‐blind, placebo‐controlled, crossover study in which all patients received placebo and oral C o Q 10 200 mg/d during the 8 weeks in each phase, with a 4‐week washout period. Participants underwent conventional and tissue Doppler echocardiography before and after each study phase. Parameters characterizing left ventricle diastolic function and other standard echocardiographic measurements were recorded. Twenty‐eight patients were randomized, but 22 patients completed study protocol. Intraventricular septum ( IVS ) thickness and left ventricle mass were significantly decreased in C o Q 10 group ( P = 0.03 and P = 0.01, respectively). Myocardial peak systolic and early diastolic velocities derived from IVS were significantly increased ( P = 0.048 and P = 0.04, respectively). Isovolumetric relaxation time and E / E m ratio calculated for IVS also significantly reduced in C o Q 10 group (p = 0.02 and p = 0.04, respectively). There was no significant difference in any of the studied echocardiographic parameters in placebo group. The results of this study showed that C o Q 10 supplementation did not significantly improved diastolic heart functions compared with placebo in maintenance hemodialysis patients.