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Management of comorbidities in haemophilia
Author(s) -
Kempton Christine L.,
Makris Michael,
Holme Pål Andre
Publication year - 2021
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.14013
Subject(s) - medicine , haemophilia , life expectancy , clotting factor , quality of life (healthcare) , hepatitis c , hepatitis c virus , incidence (geometry) , population , intensive care medicine , pediatrics , human immunodeficiency virus (hiv) , disease , immunology , virus , environmental health , physics , nursing , optics
With the introduction of clotting factor concentrates in the early 1970s, significant improvements in quality of life and life expectancy of persons with haemophilia (PWH) were realized. Unfortunately, as a result of transmission of HIV and hepatitis C virus (HCV) by contaminated concentrates in the 1980s, many of these gains were lost. Now with four decades of PWH unexposed to contaminated factor products and current treatments capable of suppressing and eliminating HIV and HCV, respectively, the survival rate is once again increasing. In addition to the usual comorbidities associated with advanced age in the general population, several specific issues occur in patients with bleeding disorders. This manuscript explores the incidence and management of the comorbidities of the ageing PWH with a focus on cardiovascular disease and osteoporosis.