Premium
Mental health disorders in haemophilia: Systematic literature review and meta‐analysis
Author(s) -
AlHuniti Ahmad,
Reyes Hernandez Melanie,
Ten Eyck Patrick,
Staber Janice M.
Publication year - 2020
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.13960
Subject(s) - medicine , anxiety , haemophilia , depression (economics) , meta analysis , cochrane library , odds ratio , medline , psychiatry , mental health , population , confidence interval , pediatrics , environmental health , political science , law , economics , macroeconomics
Aim Despite significant advances in morbidity and mortality outcomes, quality of life for people with haemophilia (PWH) remains compromised. Underrecognized and undertreated mental health disorders decrease quality of life; however, reports are inconsistent regarding the true prevalence of mental health disorders in PWH. Methods We conducted a systematic literature search of Ovid MEDLINE, EMBASE, Psychinfo and the Cochrane Library, and hand searched the journal Haemophilia to identify records and subsequently conducted a meta‐analysis to determine the prevalence of depression, anxiety and attention deficit hyperactivity disorder (ADHD) in patients with congenital haemophilia. Results Our search strategy identified 2315 records, and 28 studies met eligibility criteria. Meta‐analysis demonstrated that PWH are at increased risk of depression (odds ratio (OR) 2.45; 95% confidence interval (CI) 1.64‐3.68), anxiety (OR 1.74, 95% CI 1.01‐3.00), anxiety/depression (OR 2.60, 95% CI 2.35‐2.87) and ADHD (OR 3.48, 95% CI 1.74‐6.96). We found considerable heterogeneity among the studies likely due to differences in assessment tools, populations studied and year of publication. This suggests that standardized tools to diagnose mental health disorders in PWH are needed. Additionally, high‐quality studies investigating mental health disorders in PWH are necessary to adequately document the prevalence of these disorders. Conclusion Overall, our meta‐analysis suggests that the prevalence of depression, anxiety and ADHD across decades is significantly increased in PWH compared to the general population.