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The effects of six‐week resistance, aerobic and combined exercises on the pro‐inflammatory and anti‐inflammatory markers in overweight patients with moderate haemophilia A: A randomized controlled trial
Author(s) -
Parhampour Behrouz,
Dadgoo Mehdi,
VasaghiGharamaleki Behnoosh,
Torkaman Giti,
Ravanbod Roya,
Mirzaii-Dizgah Iraj,
Reza Baghaipour Mohammad,
Saneii Seyed Hassan
Publication year - 2019
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.13764
Subject(s) - medicine , overweight , body mass index , haemophilia , adiponectin , aerobic exercise , waist , body fat percentage , randomized controlled trial , physical therapy , obesity , gastroenterology , surgery , insulin resistance
Overweight increases the secretion of pro‐inflammatory cytokines and serves as a major risk factor for arthropathy and cardiovascular diseases (CVD). This condition is becoming increasingly prevalent among patients with haemophilia (PWH). Different forms of exercise training could favourably modify weight‐related complications, cardiovascular risk factors and the inflammation. Aim To investigate the effects of resistance, aerobic and combined exercises on the pro‐inflammatory and anti‐inflammatory markers in overweight patients with moderate haemophilia A. Methods Forty‐eight patients with moderate haemophilia A, aged 35‐55 years, and body mass index (BMI) of 25‐30 kg/m 2 were randomly assigned to resistance training (RT, n = 12), aerobic (AT, n = 12), combined training (CT, n = 12) and control (n = 12) groups. The patients participated in 45‐minutes exercise sessions three times a week for 6 weeks. Waist circumference (WC), waist‐to‐hip ratio (WHR), fat mass, fat‐free mass, interleukin‐10 (IL‐10), adiponectin, tumour necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6) and high sensitive C‐reactive protein (hs‐CRP) were measured before and after the 6 weeks of training. Results There was significant decrease in WC, WHR, BMI and weight in the AT, RT and CT groups as compared to the control group. Total HJHS scores decreased in the AT, RT, CT groups compared to the control groups ( P ≤ 0.001). The decrease in hs‐CRP, IL‐6 and TNF‐α in the CT group was significant compared to the control group ( P ≤ 0.02). The increase in IL‐10 and adiponectin was not significant in the RT, AT and CT groups compared to the control group. Conclusion CT was the most effective training mode for decreasing the pro‐inflammatory cytokines and increasing anti‐inflammatory markers in overweight patients with haemophilia A.