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Exploring regional variations in the cross‐cultural, international implementation of the Patient Reported Outcomes Burdens and Experience (PROBE) study
Author(s) -
ChaiAdisaksopha Chatree,
Skinner Mark W.,
Curtis Randall,
Frick Neil,
Nichol Michael B.,
Noone Declan,
O'Mahony Brian,
Page David,
Stonebraker Jeffrey,
Thabane Lehana,
Crowther Mark A.,
Iorio Alfonso
Publication year - 2019
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.13703
Subject(s) - haemophilia , medicine , variance (accounting) , explained variation , demography , haemophilia a , family medicine , pediatrics , statistics , mathematics , accounting , sociology , business
Background The Patient Reported Outcomes Burdens and Experience (PROBE) study has developed and validated the PROBE questionnaire for assessing patient‐reported outcomes in people with haemophilia and participants without bleeding disorders. Objective To explore the regional variations in the international implementation of the PROBE questionnaire. Methods Data were collected from participants in four regions (Western Pacific, South America, North America and Europe). Participants were able to choose English or translated versions of the PROBE questionnaire into their first language. We used analysis of variance methods and multivariable regression to determine the relative contribution of the variance explained by region controlling for haemophilia diagnosis, age group and levels of educations. We also explored interactions between region and the other components. Results We used 862 questionnaires from 14 countries. Mean age of participants was 40.03 years (standard deviation 13.89), and 73.67% were male. After adjusting, region contributed 0.44%‐7.98% of the variance component in subitem scores and 0.26% in the PROBE score. Years of education contributed 0.34% in the PROBE score. Age and haemophilia diagnosis contributed 3.42% and 22.42% of the PROBE score. Conclusions The results demonstrate that the PROBE questionnaire is valid to implement for assessing health status among patients with haemophilia and participants without bleeding disorders across regions.