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Real‐world comparative analysis of bleeding complications and health‐related quality of life in patients with haemophilia A and haemophilia B
Author(s) -
Booth Jason,
Oladapo Abiola,
Walsh Shaun,
O'Hara Jamie,
Carroll Liz,
Garcia Diego DanielAnibal,
O'Mahony Brian
Publication year - 2018
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.13596
Subject(s) - medicine , haemophilia , quality of life (healthcare) , haemophilia a , haemophilia b , confounding , incidence (geometry) , regimen , pediatrics , multivariate analysis , physical therapy , physics , nursing , optics
Clinical severity and impact of haemophilia on quality of life have been generally considered to be lower for haemophilia B ( HB ) compared with haemophilia A ( HA ) patients. Aims To compare annual bleeding rate ( ABR ), target joint development and health‐related quality of life ( HRQ oL) between adult (≥18 years) severe HA and HB patients using recent data from the Cost of Haemophilia in Europe: a Socioeconomic Survey ( CHESS ) study. Methods Multivariate generalized linear models ( GLM ) were constructed to assess the relationship between haemophilia type, ABR , HRQ oL (derived from EQ ‐5D index scores) and the presence of target joints while controlling for covariates. Results Of the 1225 patients included, 77% (n = 949) had HA and 23% (n = 278) had HB . Of the 514 patients who completed the EQ ‐5D, 78% (n = 405) had HA , and 22% (n = 110) had HB . Unadjusted mean ABR was 3.79 in HA and 4.60 in HB . The presence of ≥1 target joint was reported in 59% and 54% of patients with HA and HB , respectively. Unadjusted mean EQ ‐5D index score was 0.78 in HA and 0.76 in HB . Haemophilia type was not a significant predictor of ABR , target joints or HRQ oL when adjusted for confounding factors such as BMI , age and replacement therapy regimen. Conclusion Data suggest comparable ABR , incidence of target joints and HRQ oL between patients with HB and HA indicating comparable clinical severity and disease impact on patient quality of life.