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Risk factors for cardiovascular disease in children and young adults with haemophilia
Author(s) -
Limjoco Jacqueline,
Thornburg Courtney D.
Publication year - 2018
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.13585
Subject(s) - medicine , overweight , haemophilia , family history , obesity , waist , cohort , pediatrics , medical record , risk factor , blood pressure , physical therapy
The origins of cardiovascular disease ( CVD ) begin in childhood. The primary objective of this cross‐sectional cohort study was to determine the prevalence of cardiovascular risk factors in patients with congenital haemophilia A or B followed at Rady Children's Hospital San Diego Hemophilia and Thrombosis Treatment Center ( HTC ). We hypothesized that cardiovascular risk factors could be identified as part of a comprehensive clinic visit. Materials and Methods Standardized measurement of weight, height, waist circumference and blood pressure plus non‐fasting glucose and lipid panel were performed. Participants and/or caregivers completed questionnaires about family history, medical history and lifestyle. Clinical data were abstracted from the medical record. Descriptive statistics, Student's t test, correlation, Mann‐Whitney U test and chi‐square test were performed to analyse the data. Results Forty‐three males (mean 12 years, range 5‐20 years) enrolled. High rates of overweight and obesity, (pre)hypertension and abnormal lipids were identified. Subjects with normal weight had more days of >60 minutes of physical activity compared with those with overweight or obesity (5.2 ± 2.4 vs. 3.8 ± 2.5 day; P = 0.07). Higher weight was correlated with higher factor consumption ( cor = 0.88; P < 0.001). There was no difference in target joints based on weight category (30% in normal weight vs. 25% in overweight or obese, χ 2 = 0.11, P = 0.74), which may be attributed to high rates of prophylaxis. Conclusions Modifiable risk factors for CVD were identified as part of the study during comprehensive clinic visits. The HTC team may develop behavioural interventions to target cardiovascular risk reduction as part of the comprehensive care model.