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The spectrum of bleeding in women and girls with haemophilia B
Author(s) -
Staber J.,
Croteau S. E.,
Davis J.,
Grabowski E. F.,
Kouides P.,
Sidonio R. F.
Publication year - 2018
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.13376
Subject(s) - medicine , haemophilia , haemophilia b , haemophilia a , pediatrics
Although hemophilia B affects 1 in 25,000 males there may be 3 female hemophilia B carriers per affected male. This clinical review highlights the unique challenges faced by hemophilia B carriers including the under‐recognition of bleeding symptoms associated with and without FIX deficiency, discrepancies in correlation between genotype and bleeding phenotype and therapeutic considerations utilizing clinical vignettes of common scenarios.