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Radionuclide synovectomy/synoviorthesis ( RS ) in patients with bleeding disorders: A review of patient and procedure demographics and functional outcomes in the ATHN dataset
Author(s) -
McGuinn C.,
Cheng D.,
Aschman D.,
Carpenter S. L.,
Sidonio R.,
Soni A.,
Tarantino M. D.,
Wheeler A. P.,
Dunn A. L.
Publication year - 2017
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.13318
Subject(s) - medicine , haemophilia , demographics , haemophilia a , observational study , synovectomy , synovitis , cohort , surgery , demography , arthritis , rheumatoid arthritis , sociology
Radionuclide synovectomy/synoviorthesis ( RS ) to manage proliferative synovitis in persons with bleeding disorders has been utilized for decades; however, aggregate US results are limited. Aim To determine the prevalence of RS utilization, patient and procedure related demographics and functional outcomes in United States haemophilia treatment centres ( HTC s). The ATHN dataset includes US patients with bleeding disorders who have authorized the sharing of their demographic and clinical information for research. Methods We performed a multi‐institutional, observational cohort study utilizing this dataset through 2010. Cases treated with RS procedure were compared to controls within the dataset. Standard template for data collection included patient and procedure related demographics as well as functional outcomes including range of motion ( ROM ) of the affected joint. Normative age‐ and sex‐matched control ROM was obtained from published data. Results In the ATHN dataset there were 19 539 control‐patients and 196 case‐patients treated with RS . Patients with severe haemophilia were more likely to have had RS compared to those with mild/moderate haemophilia, although the proportion of RS performed was similar between severe HA and HB . Inhibitory antibodies, HIV and hepatitis C infection were significantly more common in cases. There were 362 RS procedures captured with 94 cases having >1 RS procedures. Conclusions Right‐sided joint procedures were more prevalent than left‐sided procedures. Overall, case‐patients had worse joint ROM compared to control‐patients and published normative values. Geographically, there was regional variation in RS utilization, as the Southeast region had the largest percent of case‐patients.