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The effects of joint disease, inhibitors and other complications on health‐related quality of life among males with severe haemophilia A in the United States
Author(s) -
Soucie J. M.,
Grosse S. D.,
Siddiqi A.E.A.,
Byams V.,
Thierry J.,
Zack M. M.,
Shapiro A.,
Duncan N.
Publication year - 2017
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.13275
Subject(s) - haemophilia , medicine , overweight , haemophilia a , quality of life (healthcare) , bivariate analysis , obesity , disease , multivariate analysis , body mass index , physical therapy , demography , pediatrics , statistics , nursing , mathematics , sociology
Health‐related quality of life ( HRQ oL) is reduced among persons with haemophilia. Little is known about how HRQ oL varies with complications of haemophilia such as inhibitors and joint disease. Estimates of preference‐based HRQ oL measures are needed to model the cost‐effectiveness of prevention strategies. Aim We examined the characteristics of a national sample of persons with severe haemophilia A for associations with two preference‐based measures of HRQ oL. Methods We analysed utility weights converted from EuroQol 5 Dimensions ( EQ ‐5D) and the Short Form 6 Dimensions ( SF ‐6D) scores from 1859 males aged ≥14 years with severe haemophilia A treated at 135 US haemophilia treatment centres in 2005‐2011. Bivariate and regression analyses examined age‐group‐specific associations of HRQ oL with inhibitor status, overweight/obesity, number of bleeds, viral infections, indicators of liver and joint disease, and severe bleeding at the time of the first HRQ oL measurement. Results Overall mean HRQ oL utility weight values were 0.71 using the SF ‐6D and 0.78 using the EQ ‐5D. All studied patient characteristics except for overweight/obesity were significantly associated with HRQ oL in bivariate analyses. In a multivariate analysis, only joint disease was significantly associated with utility weights from both HRQ oL measures and across all age groups. After adjustment for joint disease and other variables, the presence of an inhibitor was not significantly associated with HRQ oL scores from either of the standardized assessment tools. Conclusion Clinically significant complications of haemophilia, especially joint disease, are strongly associated with HRQ oL and should be accounted for in studies of preference‐based health utilities for people with haemophilia.