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Retrospective analysis of in vivo recovery and clearance during continuous infusion of recombinant factor VIII products: a single‐institution study
Author(s) -
Suzuki N.,
Hirakawa A.,
Kishimoto M.,
Kanematsu T.,
Ogawa M.,
Kiyoi H.,
Matsushita T.
Publication year - 2017
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.13082
Subject(s) - medicine , haemophilia , body mass index , univariate analysis , multivariate statistics , multivariate analysis , univariate , hepatitis c virus , gastroenterology , surgery , immunology , virus , statistics , mathematics
Background Continuous infusion ( CI ) of recombinant FVIII ( rFVIII ) concentrates has been reported as an effective and safe method to achieve haemostasis during major surgeries or severe bleeding events. For more effective and safer CI , better understanding of in vivo recovery ( IVR ) and clearance ( CL ) issues is imperative. Objective We investigated the following factors affecting IVR and CL using univariate and multivariate regression analyses during 47 CI s in 34 patients: rFVIII concentrate type, haemophilia severity, blood type, the presence of hepatitis C virus ( HCV ) or human immunodeficiency virus ( HIV ), age and body mass index ( BMI ). Results The mean IVR was 1.64 ± 0.49 IU dL −1 per IU kg −1 , and the mean CL during CI was 3.56 ± 1.57 mL h −1 kg −1 . The univariate and multivariate regression analyses showed that the CL of octocog alfa was significantly lower than that of rurioctocog alfa ( P = 0.043 and 0.0034, respectively). There was a significant difference in BMI in the univariate and multivariate regression analyses ( P = 0.0403 and 0.0376, respectively). Conclusions This study indicated that CL during CI was potentially affected by the type of rFVIII concentrate used and BMI .