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Potential biomarkers of haemophilic arthropathy: correlations with compatible additive magnetic resonance imaging scores
Author(s) -
Oldenburg J.,
Zimmermann R.,
Katsarou O.,
Za E.,
Kellermann E.,
Lundin B.,
Ellinghaus P.
Publication year - 2016
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.12936
Subject(s) - medicine , cartilage oligomeric matrix protein , magnetic resonance imaging , arthropathy , etanercept , cartilage , arthritis , osteoarthritis , biomarker , vascular endothelial growth factor , rheumatoid arthritis , gastroenterology , pathology , radiology , vegf receptors , biochemistry , chemistry , alternative medicine , anatomy
Although biomarkers are useful diagnostic tools to assess joint damage in osteoarthritis and rheumatoid arthritis, few data exist for biomarkers of haemophilic arthropathy. Aim To evaluate the association between biomarkers and compatible additive magnetic resonance imaging ( MRI ) scores in patients with severe haemophilia A. Methods Patients aged 12–35 years with no history of factor VIII ( FVIII ) inhibitors were enrolled in a controlled, cross‐sectional, multinational investigation. Patients received primary or secondary prophylaxis or on‐demand treatment with FVIII and underwent MRI on four joints (two ankles, two knees). Soluble biomarkers of cartilage and bone degradation, inflammation, and angiogenesis were assessed (serum levels of C‐terminal telopeptides of type I collagen [ CTX ‐I], cartilage oligomeric matrix protein [ COMP ], chondroitin‐sulphate aggrecan turnover 846 epitope [ CS 846], tissue inhibitor of metalloproteinase 1 [ TIMP ‐1]; plasma levels of vascular endothelial growth factor [ VEGF ], matrix metalloproteinases 3 and 9 [ MMP 3, MMP 9]). Relationships between biomarkers and MRI scores were evaluated using Spearman rank correlation. Results Biomarkers were assessed in 117 of 118 per‐protocol patients. Mean and median CTX ‐I, COMP , TIMP ‐1, MMP 3, MMP 9, and VEGF values were within normal ranges (reference range not available for CS 846 in healthy volunteers). No correlations between biomarkers and MRI scores were found, with the exception of CS 846, which showed significant correlation in a subgroup of 22 on‐demand patients ( r = 0.436; P = 0.04). Conclusions Compatible additive MRI scores showed no clear correlations with any of the potential biomarkers for haemophilic arthropathy in the overall population. CS 846 levels were significantly correlated with MRI scores in patients treated on demand.