Premium
Impact of being overweight on factor VIII dosing in children with haemophilia A
Author(s) -
Henrard S.,
Hermans C.
Publication year - 2016
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.12848
Subject(s) - medicine , percentile , body mass index , dosing , overweight , haemophilia , haemophilia a , body weight , pediatrics , statistics , mathematics
Treatment of haemophilia A ( HA ) requires infusions of factor VIII ( FVIII ) concentrates. The number of FVIII units infused to obtain a specific circulating FVIII level is calculated with the formula: [body weight ( BW ) (kg) × desired FVIII increase (%)]/2, with the assumption that each unit of FVIII infused per kg of BW increases the circulating FVIII level by 2%. Aim The aim of this study was to evaluate the impact of several morphometric parameters ( BW , body mass index ( BMI )‐for‐age, height), age and type of FVIII concentrate on FVIII recovery in children with HA . Methods A total of 66 children aged between 10 and 18 with severe HA selected from six pharmacokinetic (PK) clinical trials using two recombinant FVIII concentrates were included in the analysis. Regression tree ( RT ) was used to identify predictors of FVIII recovery. Results The median age was 14.5 years with a median FVIII recovery of 2.09 for all children. The median FVIII recovery was not significantly different between age groups. Two groups were created by RT : children with a BMI ‐for‐age percentile