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Inhibitors to factor VII in congenital factor VII deficiency
Author(s) -
Batorova A.,
Mariani G.,
Kavakli K.,
Saez A. R.,
Caliskan Ü.,
Karimi M.,
Pinotti M.,
Napolitano M.,
Dolce A.,
Sørensen B.,
Ingerslev J.
Publication year - 2014
Publication title -
haemophilia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.213
H-Index - 92
eISSN - 1365-2516
pISSN - 1351-8216
DOI - 10.1111/hae.12376
Subject(s) - haemophilia , medicine , university hospital , library science , pediatrics , family medicine , computer science
We performed a prospective study of FVII inhibitor\udoccurrence in a large number of patients with FVII\uddeficiency who had received replacement therapy for\udspontaneous or traumatic bleeding episodes, major or\udminor surgical interventions or prophylaxis.Inhibitor development was detected in 2.6% (3/115)\udof patients, but the incidence of de novo inhibitors\udwas 0.8% (1/115). Thus, in this rare bleeding disorder,\udthe development of FVII inhibitors is a very rare\udcomplication as rare as that reported in patients with\udhaemophilia B (prevalence of 2–3%
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